We are TAE Life Sciences

Position Summary: We are seeking a highly motivated chemist with solid grounding in organic chemistry and an interest in medicinal chemistry. The successful candidate will join our Chemistry Group to work on projects in the pursuit of novel bioconjugates and small molecules utilized in boron neutron capture therapy for curing diseases including cancer.

• An individual with a strong background in synthetic organic/medicinal chemistry. The successful candidate will be responsible for developing synthetic routes and chemical processes for small molecule prodrugs, and polymers for conjugation to biomolecules.
• The tasks include
  • Performing research in the laboratory as synthetic and medicinal chemist
  • Design and execute synthesis of organic molecules and biopolymers
  • Critically evaluate relevant scientific advances and integrate this knowledge into research programs
  • Instrumental in the intellectual property generation and patent filing
• This role works in a collaborative environment with cell biology / antibody generation & pharmacology group
• Experience in either bioconjugation chemistry or boron chemistry is a plus

About the company: TAE Life Sciences is a technology and precision medicine company based in Foothill Ranch and Santa Monica, California. Our mission is to transform the clinical management and treatment of cancer via innovative and tissue sparing neutron radiation therapy known as BNCT. We re-engineer therapeutic antibodies against biologically important targets and enable them with the ability to deliver boron to tumor followed by neutron radiation to eradicate cancer cells by an in situ alpha-particle generation nuclear fission reaction, while sparing the non-cancer i.e. normal cells. Our first neutron beam medical device, Alpha Beam™, is due to be commissioned in Xiamen, China at the end of 2022.

Job Location: California, USA

Essential Duties and Responsibilities:

• Work effectively with multidisciplinary team
• Help maintain lab in a clean and orderly way
• Articulate issues and options for resolution to upper management in a timely manner
• Write reports on work and accomplishments
• Present work at lab meetings
• Present summary data to multi-disciplinary team
• Lead molecules design and implementation and optimization using SAR and medicinal chemistry approaches
• Optimize multiple parameters during lead generation effort based on strong knowledge of medicinal chemistry and understanding of key ADME, biochemical and pharmacological
  principles
• Provide oversight for the transfer of chemical processes to third party CRO or CMO and
  develop novel and creative solutions to processing problems
• Publish research in peer-reviewed journals

Required Qualifications:

• Doctoral level degree in synthetic organic or medicinal chemistry.
• Additional post-doctoral experience or Industrial experience in developing synthetic routes and chemical processes for active pharmaceutical ingredients is preferred
• Highly proficient in advanced synthetic, purification and spectroscopic techniques utilized in the preparation and characterization of organic molecules
• Inorganic boron chemistry experience, drug-linker experience for ADC/ liposome chemistry knowledge are a plus
• Strong track record of achievement in synthesis of complex molecules with state of the art knowledge of modern synthetic methodologies and analytical and purification
  techniques
• Expertise in methodology development and successfully completed multistep syntheses
• Excellent written and oral communication skills; enthusiasm, integrity, self-motivation,
  and ability to interact within a multi-disciplinary team
• Proficient in business and lab software
• Strong adherence to laboratory safety practices

Position Summary: We are seeking a highly motivated and committed individual to apply scientific principles to all aspects of developing antibody and antibody fragment conjugates. The successful candidate will have experience in bioconjugation of proteins with a variety of moieties including boron enriched linkers, polymers and fluorophores. The individual should be adapt at performing purification techniques including ultrafiltration, UF/DF and chromatography and a variety of analytical methods used for characterization including HPLC, SDS-PAGE, fluorescence and other appropriate analytical techniques. As a member of the Chemistry team, the candidate will support bioconjugation process development efforts by performing routine laboratory experiments, meticulously documenting the data, presenting his work to the rest of the team.
Prior experience with ADC and antibody conjugation, chromatography and statistical analysis DOE approach is a plus. The candidate will interact with in-house research group and foster the development of new technologies. The ideal scientist will be drive innovation, solve technical problems, and work well as a member of a team.

About the company: TAE Life Sciences is a technology and precision medicine company based in Foothill Ranch and Santa Monica, California. Our mission is to transform the clinical management and treatment of cancer via innovative and tissue sparing neutron radiation therapy known as BNCT. We re-engineer therapeutic antibodies against biologically important targets and enable them with the ability to deliver boron to tumor followed by neutron radiation to eradicate cancer cells by an in situ alpha-particle generation nuclear fission reaction, while sparing the non-cancer i.e. normal cells. Our first neutron beam medical device, Alpha Beam™, is due to be commissioned in Xiamen, China at the end of 2022.

Job Location: California, USA

Essential Duties and Responsibilities:

• Conjugation of monoclonal antibodies with polymers, peptides and boron-enriched linkers at the early research stage
• Characterize the respective antibody product and conjugated products using analytic assays that include reverse phase HPLC, SEC HPLC, electrophoresis and ICP OES.
• Assist in the development of scalable, robust, efficient, and innovative chemical and biochemical conjugation processes suitable for clinical material production and subsequent commercialization
• Interact with CROs regarding analytical characterization when necessary
• Responsible for writing protocols and reports describing conjugation processes and analytic assays, as well as contributing to regulatory filings
• Communicate results in a timely manner and collaborate with internal and external development teams.

Required Qualifications:

• BS or MS degree in Biochemistry, Chemical Engineering, Chemistry, or a related fields with at least 3 years of industry experience
• 2 years of experience of handling, purifying and analyzing proteins, antibodies
• Experience with antibody conjugation and ADC is a plus
• Writing of CMC study reports and SOPs
• Must be highly motivated with excellent organizational and communication skills
• Must be able to work independently and as part of a multi-disciplinary team, with the ability to work in a dynamic, fast paced environment